
Most common option found online is using builtin option Run. I also wanted to run python files directly from Notepad++. I don't know where or how you do this, but in trying various things here, I was able to do that-I don't recall which attempt did the trick. Somewhere I think you have to tell NPP where the Python.exe file is (e.g., for me: C:\Python33\python.exe).
#NOTEPAD++ PYTHON RUN WINDOWS#
& is unconditional execution of the next command in Windows - unconditional as it runs regardless of the RC of the previous command ( & is "and" - run only if the previous completed successfully, || - is "or").

#NOTEPAD++ PYTHON RUN INSTALL#
If that is too much typing for your liking (for me it sure is :), the Run command to use is cmd /k C:\Python27\python.exe "$(FULL_CURRENT_PATH)" & pause & exitĬ:\Python27\python.exe - obviously the full path to your python install (or just python if you want to go with the first executable in your user's path). Yet in cmd /k you have to type exit to close it, in the python -i - quit(). All the answers for the Run->Run menu option go with the "/K" switch of cmd, so the terminal stays open, or "-i" for python.exe so python forces interactive mode - both to preserve the output for you to observe.
